
I’ve been reflecting on something that often surfaces in my work, both in the IVF clinic and as an angel investor. It’s the notion of uncertainty, and how, surprisingly, it can be a source of comfort rather than anxiety. This might seem counterintuitive, especially in a world that constantly pushes us to mitigate risks and seek guarantees. Yet, in the realm of IVF, as with startups, embracing the unknown often yields unexpected strength.
Just last week, I sat with a couple embarking on their first IVF cycle. The room was thick with anticipation and a touch of dread. They were acutely aware of the statistics — the success rates that hover around 34.6% in Europe, for instance — and the emotional rollercoaster that lay ahead. Yet, amidst the anxiety, there was also a palpable sense of hope. It struck me how similar this was to the hopeful yet uncertain journey of a startup founder seeking funding.
In both fields, the initial optimism often gives way to a more nuanced understanding of the journey. The first cycle of IVF, much like a startup’s first round of funding, is fraught with hope but also the stark reality of potential failure. Many founders are buoyant at the start, much like IVF patients filled with hope for a first-time success. But as cycles or rounds progress, the optimism often wanes, replaced by a more grounded resilience.
This parallel isn’t just a poetic observation. It has practical implications for how we navigate these journeys. In the medical field, we often prepare patients for the physical demands of IVF — the hormone injections, the invasive procedures. However, the emotional toll is equally significant. The journey is unpredictable and can be heart-wrenching, especially when faced with the disappointment of a failed cycle. Yet, this very unpredictability can be a wellspring of resilience. Each setback becomes a lesson, each uncertainty a chance to fortify one’s resolve.
In the startup world, too, the path is rarely linear. Founders face pivots, funding rejections, and market shifts. But those who thrive are often those who embrace these uncertainties rather than shy away from them. They understand that certainty is a mirage; the real progress is made in the fog of the unknown.
This is where the surprising comfort of uncertainty lies. It’s not about blind optimism or reckless risk-taking. Rather, it’s about acknowledging the limits of our control and finding strength in that acceptance. In the IVF clinic, I’ve seen couples who, despite repeated failures, find deeper connections with each other and a clearer sense of purpose. Similarly, in my investments, I’ve seen founders who, after navigating uncertainty, emerge with a stronger, more resilient company.
One might wonder if there’s a way to ‘teach’ this comfort in uncertainty. While there’s no formula, there are practices that can help. For IVF patients, it’s crucial to build a strong support system and to manage expectations realistically. The emotional and psychological preparation is as important as the physical. For founders, it’s about developing a thick skin and a flexible mindset. The ability to pivot, to reassess goals, and to find opportunity in setbacks is invaluable.
I’ve written before about why IVF and startups both thrive on uncertainty. This isn’t just theoretical musing; it’s a reflection of the lived experiences of those who navigate these paths. The key is not to eliminate uncertainty but to learn to dance with it.
At the end of the day, both IVF and startup ventures are deeply personal journeys. They challenge us to confront our deepest fears and desires, to question what we truly want and what we’re willing to endure to achieve it. In doing so, they reveal the surprising comfort in uncertainty — the realization that, while we may not control the outcome, we do control how we respond to the journey.
As I continue to work with patients and founders, I’m reminded that embracing the unknown is not just a necessity; it’s a profound opportunity for growth. Whether you’re on the cusp of parenthood through IVF or the brink of launching the next big startup, my advice is this: lean into the uncertainty. It’s where the most meaningful lessons reside.